gan lab
neurological disease
Publications
PEER REVIEWED PUBLICATIONS
- Krabbe G, Minami SS, Etchegaray JI, Taneja P, Djukic B, Davalos D, Le D, Lo I, Zhan L1, Reichert MC1, Sayed F, Merlini M, Ward ME, Perry DC, Lee SE, Sias A, Parkhurst CN, Gan WB, Akassoglou K, Miller BL, Farese RV Jr, Gan L.(2017) Microglial NFκB-TNFα hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia.PNAS. 2017 May 9;114(19):5029-5034. PMID: 28438992. PMCID: PMC5441749
- Ward ME, Chen R, Huang HY, Ludwig C, Telpoukhovskaia M, Taubes A, Boudin H, Minami SS, Reichert M, Albrecht P, Gelfand JM, Cruz-Herranz A, Cordano C, Alavi MV, Leslie S, Seeley WW, Miller BL, Bigio E, Mesulam MM, Bogyo MS, Mackenzie IR, Staropoli JF, Cotman SL, Huang EJ, Gan L*, Green AJ*. (2017) Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis.Sci Transl Med. 2017 Apr 12;9(385). PMID: 28404863. PMCID: PMC5526610 (*co-corresponding authors)
- Tracy TE, Gan L. (2017) Acetylated tau in Alzheimer's disease: An instigator of synaptic dysfunction underlying memory loss: Increased levels of acetylated tau blocks the postsynaptic signaling required for plasticity and promotes memory deficits associated with tauopathy. Bioessays. 2017 Apr;39(4). PMID: 28083916
- Wes PD, Sayed FA, Bard F, Gan L. (2016) Targeting microglia for the treatment of Alzheimer's Disease. Glia. 64(10):1710-32. PubMed PMID: 27100611
- Möller T, Bard F, Bhattacharya A, Biber K, Campbell B, Dale E, Eder C, Gan L, Garden GA, Hughes ZA, Pearse DD, Staal RG, Sayed FA, Wes PD, Boddeke HW. (2016) Critical data-based re-evaluation of minocycline as a putative specific microglia inhibitor. Glia. 64(10):1788-94. PubMed PMID: 27246804
- Sohn PD, Tracy TE, Son HI, Zhou Y, Leite R.E.P, Miller B, Seeley W.W, Grinberg LT, and Gan L. Acetylated Tau Destabilizes the Cytoskeleton in the Axon Initial Segment and Is Mislocalized to the Somatodendritic Compartment. Mol. Neurodegener. 2016 Jun 29;11(1)47. PMID: 27356871 PMCID: PMC4928318
- Tracy TE, Sohn PD, Minami SS, Wang C, Min SW, Li Y, Zhou Y, Le D, Lo I, Ponnusamy R, Cong X, Schilling B, Ellerby LM, Huganir RL and Gan L. Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss. Neuron. 2016 Apr 20;90(2):245-60. PMID: 27041503 PMCID: PMC4859346
- Min S, Chen X, Tracy TE, Li Y., Zhou Y., Wang C, Shirakawa K, Minami SS, Defensor E., Mok SA, Sohn PD, Schiling B, Cong X, Ellerby L, Gibson BW, Johnson J, Krogan N, Shamloo M, Gestwicki J, Masliah E, D, Verdin E and Gan L. Critical Role of Acetylation in Tau-mediated Neurodegeneration and Cognitive Deficits: Therapeutic Implications. Nat. Med. 2015 Oct;21(10):1154-1162. PMID: 26390242 PMCID: PMC4598295
- Minami SS, Shen V, Le D, Krabbe G, Asgarov R, Perez-Celajes L, Lee CH, Li J, Donnelly-Roberts D, and Gan L. Reducing inflammation and rescuing FTD-related behavioral deficits in progranulin-deficient mice with α7 nicotinic acetylcholine receptor agonists. Biochem. Pharmacol. 2015 Oct 15;97(4):454-62. PMID: 26206194 PMCID: PMC4859338
- Cho SH, Chen JA, Sayed F, Ward ME, Gao F, Nguyen TA, Krabbe G, Sohn PD, Lo I, Minami S, Devidze N, Zhou Y, Coppola G, Gan L. SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1β. J Neurosci. 2015 Jan 14;35(2):807-18. PMID: 25589773. PMCID: PMC4293425
- Minami SS, Min S, Krabbe G, Zhou Y, Asgarov R, Herl-Martens L, Elia L, Ward ME, Mucke L., Farese RV, Jr., and Gan L. Progranulin modulates innate immunity and protects against amyloid b-mediated toxicity in mouse models of Alzheimer’s Disease. Nat. Med. 2014 Oct;20(10):1157-64. PMID: 25261995 PMCID: PMC4196723
- Ward ME, Taubes A, Miller BL, Chen R, Sephton CF, Gelfand J, Boscardin J, Martens LH, Seeley WW, Yu G, Herz J, Farese RV Jr., Green A, and Gan L. Reduced expression of Ran and nuclear depletion of TDP-43 plays an essential role in progranulin-deficient FTLD. J. Exp. Med. 2014 Sept; 22;211(10):1937-45. PMID: 25155018. PMCID: PMC4172214
- Min SW, Sohn PD, Cho SH, Swanson RA, Gan L. Sirtuins in neurodegenerative diseases: an update on potential mechanisms. Front Aging Neurosci. 2013; 5:53. PMID: 24093018. PMCID: PMC3782645
- Kauppinen TM, Gan L, Swanson RA. Poly(ADP-ribose) polymerase-1-induced NAD(+) depletion promotes nuclear factor-KB transcriptional activity by preventing p65 de-acetylation. Biochim Biophys Acta. 2013 Aug; 1833(8):1985-91. PMID: 23597856. PMCID: PMC4041949
- Grinberg LT, Wang X, Wang C, Sohn PD, Theofilas P, Sidhu M, Arevalo JB, Heinsen H, Huang EJ, Rosen H, Miller BL, Gan L, Seeley WW. Argyrophilic grain disease differs from other tauopathies by lacking tau acetylation. Acta Neuropathol. 2013 Apr; 125(4):581-93. PMID: 23371364. PMCID: PMC3692283
- Pappas DJ, Gabatto PA, Oksenberg D, Khankhanian P, Baranzini SE, Gan L, Oksenberg JR. Transcriptional expression patterns triggered by chemically distinct neuroprotective molecules. Neuroscience. 2012 Dec 13; 226:10-20. PMID: 22986168. PMCID: PMC3489981
- Martens LH, Zhang J, Barmada SJ, Zhou P, Kamiya S, Sun B, Min SW, Gan L, Finkbeiner S, Huang EJ, Farese RV. Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury. J Clin Invest. 2012 Nov 1; 122(11):3955-9. PMID: 23041626. PMCID: PMC3484443
- Wang C, Sun B, Zhou Y, Grubb A, Gan L. Cathepsin B degrades amyloid-ß in mice expressing wild-type human amyloid precursor protein. J Biol Chem. 2012 Nov 16; 287(47):39834-41. PMID: 23024364. PMCID: PMC3501032
- Minami SS, Sun B, Popat K, Kauppinen T, Pleiss M, Zhou Y, Ward ME, Floreancig P, Mucke L, Desai T, Gan L. Selective targeting of microglia by quantum dots. J Neuroinflammation. 2012; 9:22. PMID: 22272874. PMCID: PMC3292839
- Zhang F, Wang S, Gan L, Vosler PS, Gao Y, Zigmond MJ, Chen J. Protective effects and mechanisms of sirtuins in the nervous system. Prog Neurobiol. 2011 Nov; 95(3):373-95. PMID: 21930182. PMCID: PMC3242010
- Cho SH, Sun B, Zhou Y, Kauppinen TM, Halabisky B, Wes P, Ransohoff RM, Gan L. CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease. J Biol Chem. 2011 Sep 16; 286(37):32713-22. PMID: 21771791. PMCID: PMC3173153
- Kauppinen TM, Suh SW, Higashi Y, Berman AE, Escartin C, Won SJ, Wang C, Cho SH, Gan L, Swanson RA. Poly(ADP-ribose)polymerase-1 modulates microglial responses to amyloid ß. J Neuroinflammation. 2011; 8:152. PMID: 22051244. PMCID: PMC3247192
- Min SW, Cho SH, Zhou Y, Schroeder S, Haroutunian V, Seeley WW, Huang EJ, Shen Y, Masliah E, Mukherjee C, Meyers D, Cole PA, Ott M, Gan L. Acetylation of tau inhibits its degradation and contributes to tauopathy. Neuron. 2010 Sep 23; 67(6):953-66. PMID: 20869593. PMCID: PMC3035103
- Sun B, Halabisky B, Zhou Y, Palop JJ, Yu G, Mucke L, Gan L. Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer's Disease. Cell Stem Cell. 2009 Dec 4; 5(6):624-33. PMID: 19951690. PMCID: PMC2823799
- Sanchez-Mejia RO, Newman JW, Toh S, Yu GQ, Zhou Y, Halabisky B, Cissé M, Scearce-Levie K, Cheng IH, Gan L, Palop JJ, Bonventre JV, Mucke L. Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease. Nat Neurosci. 2008 Nov; 11(11):1311-8. PMID: 18931664. PMCID: PMC2597064
- Sun B, Zhou Y, Halabisky B, Lo I, Cho SH, Mueller-Steiner S, Devidze N, Wang X, Grubb A, Gan L. Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease. Neuron. 2008 Oct 23; 60(2):247-57. PMID: 18957217. PMCID: PMC2755563
- Gan L, Mucke L. Paths of convergence: sirtuins in aging and neurodegeneration. Neuron. 2008 Apr 10; 58(1):10-4. PMID: 18400158
- Mueller-Steiner S, Zhou Y, Arai H, Roberson ED, Sun B, Chen J, Wang X, Yu G, Esposito L, Mucke L, Gan L. Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease. Neuron. 2006 Sep 21; 51(6):703-14. (Commented in Neuron and Lancet Neurology.) PMID: 16982417
- .Chen J, Zhou Y, Mueller-Steiner S, Chen LF, Kwon H, Yi S, Mucke L, Gan L. SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling. J Biol Chem. 2005 Dec 2; 280(48):40364-74. PMID: 16183991
- Kaczmarek LK, Bhattacharjee A, Desai R, Gan L, Song P, von Hehn CA, Whim MD, Yang B. Regulation of the timing of MNTB neurons by short-term and long-term modulation of potassium channels. Hear Res. 2005 Aug; 206(1-2):133-45. PMID: 16081004
- Esposito L*, Gan L*, Yu GQ, Essrich C, Mucke L. Intracellularly generated amyloid-beta peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells. J Neurochem. 2004 Dec; 91(6):1260-74. PMID: 15584903 (*, authors contribute equally)
- Gresch O, Engel FB, Nesic D, Tran TT, England HM, Hickman ES, Körner I, Gan L, Chen S, Castro-Obregon S, Hammermann R, Wolf J, Müller-Hartmann H, Nix M, Siebenkotten G, Kraus G, Lun K. New non-viral method for gene transfer into primary cells. Methods. 2004 Jun; 33(2):151-63. PMID: 15121170
- Gan L*, Ye S, Chu A, Anton K, Yi S, Vincent VA, von Schack D, Chin D, Murray J, Lohr S, Patthy L, Gonzalez-Zulueta M, Nikolich K, Urfer R. Identification of cathepsin B as a mediator of neuronal death induced by Abeta-activated microglial cells using a functional genomics approach. J Biol Chem. 2004 Feb 13; 279(7):5565-72. (*Corresponding author) PMID: 14612454
- Ford BD, Liu Y, Mann MA, Krauss R, Phillips K, Gan L, Fischbach GD. Neuregulin-1 suppresses muscarinic receptor expression and acetylcholine-activated muscarinic K+ channels in cardiac myocytes. Biochem Biophys Res Commun. 2003 Aug 15; 308(1):23-8. PMID: 12890474
- Bhattacharjee A, Gan L, Kaczmarek LK. Localization of the Slack potassium channel in the rat central nervous system. J Comp Neurol. 2002 Dec 16; 454(3):241-54. PMID: 12442315
- Gan L, Anton KE, Masterson BA, Vincent VA, Ye S, Gonzalez-Zulueta M. Specific interference with gene expression and gene function mediated by long dsRNA in neural cells. J Neurosci Methods. 2002 Dec 15; 121(2):151-7. PMID: 12468005
- Gan L, Hahn SJ, Kaczmarek LK. Cell type-specific expression of the Kv3.1 gene is mediated by a negative element in the 5' untranslated region of the Kv3.1 promoter. J Neurochem. 1999 Oct; 73(4):1350-62. PMID: 10501178
- Xu X, Yang D, Wyss-Coray T, Yan J, Gan L, Sun Y, Mucke L. Wild-type but not Alzheimer-mutant amyloid precursor protein confers resistance against p53-mediated apoptosis. Proc Natl Acad Sci U S A. 1999 Jun 22; 96(13):7547-52. PMID: 10377452. PMCID: PMC22123
- Joiner WJ, Tang MD, Wang LY, Dworetzky SI, Boissard CG, Gan L, Gribkoff VK, Kaczmarek LK. Formation of intermediate-conductance calcium-activated potassium channels by interaction of Slack and Slo subunits. Nat Neurosci. 1998 Oct; 1(6):462-9. PMID: 10196543
- Gan L, Kaczmarek LK. When, where, and how much? Expression of the Kv3.1 potassium channel in high-frequency firing neurons. J Neurobiol. 1998 Oct; 37(1):69-79. PMID: 9777733
- Wang LY, Gan L, Forsythe ID, Kaczmarek LK. Contribution of the Kv3.1 potassium channel to high-frequency firing in mouse auditory neurones. J Physiol. 1998 May 15; 509 ( Pt 1):183-94. PMID: 9547392. PMCID: PMC2230948
- Wang LY, Gan L, Perney TM, Schwartz I, Kaczmarek LK. Activation of Kv3.1 channels in neuronal spine-like structures may induce local potassium ion depletion. Proc Natl Acad Sci U S A. 1998 Feb 17; 95(4):1882-7. PMID: 9465111. PMCID: PMC19207
- Gan L, Perney TM, Kaczmarek LK. Cloning and characterization of the promoter for a potassium channel expressed in high frequency firing neurons. J Biol Chem. 1996 Mar 8; 271(10):5859-65. PMID: 8621457
- Kanemasa T, Gan L, Perney TM, Wang LY, Kaczmarek LK. Electrophysiological and pharmacological characterization of a mammalian Shaw channel expressed in NIH 3T3 fibroblasts. J Neurophysiol. 1995 Jul; 74(1):207-17. PMID: 7472324
