Original Research Articles (peer reviewed)

  1. Mucke L, Norita M, Benedek G, and Creutzfeldt OD (1982) Physiologic and anatomic investigation of a visual cortical area situated in the ventral bank of the anterior ectosylvian sulcus of the cat. Exp. Brain. Res. 46: 1–11
  2. Norita M, Mucke L, Benedek G, Albowitz B, Katoh Y, and Creutzfeldt OD (1986) Connections of the anterior ectosylvian visual area (AEV). Exp. Brain. Res. 62: 225–240
  3. Schalling M, Dagerlind A, Brene S, Petterson R, Kvist S, Brownstein M, Hyman SE, Mucke L, Goodman HM, Joh TH, Goldstein M, and Hökfelt T (1987) Localization of mRNA for phenylethanolamine N-methyltransferase (PNMT) using in situ hybridization. Acta Physiol. Scand. 131: 631–632
  4. Berger JR and Mucke L (1988) Prolonged survival and partial recovery in AIDS-associated progressive multifocal leukoencephalopathy. Neurology 38: 1060–1065
  5. Ross ME, Evinger MJ, Hyman SE, Carroll JM, Mucke L, Comb M, Reis DJ, Joh TH, and Goodman HM (1990) Identification of a functional glucocorticoid response element in the phenylethanolamine N-methyltransferase promoter using fusion genes introduced into chromaffin cells in primary culture. J. Neurosci. 10: 520–530
  6. Joly E, Mucke L, and Oldstone MBA (1991) Viral persistence in neurons explained by a lack of major histocompatibility class I expression. Science 253: 1283–1285
  7. Mucke L, Oldstone MBA, Morris JC, and Nerenberg MI (1991) Rapid activation of astrocyte-specific expression of GFAP-lacZ transgene by focal injury. New Biol. 3: 465–474
  8. Mucke L and Oldstone MBA (1992) The expression of major histocompatibility complex (MHC) class I antigens in the brain differs markedly in acute and persistent infections with lymphocytic choriomeningitis virus (LCMV). J. Neuroimmunol. 36: 193–198
  9. Abraham CR, Kanemaru K, and Mucke L (1993) Expression of cathepsin G-like and a1-antichymotrypsin-like proteins in reactive astrocytes. Brain Res. 621: 222–232
  10. Campbell IL, Abraham CR, Masliah E, Kemper P, Inglis JD, Oldstone MBA, and Mucke L (1993) Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6. Proc. Natl. Acad. Sci. USA 90: 10061–10065
  11. Mucke L and Rockenstein EM (1993) Prolonged delivery of transgene products to specific brain regions by migratory astrocyte grafts. Transgenics 1: 3–9
  12. Mucke L, Masliah E, Johnson WB, Ruppe MD, Alford M, Rockenstein EM, Forss-Petter S, Pietropaolo M, Mallory M, and Abraham CR (1994) Synaptotrophic effects of human amyloid b protein precursor in the cortex of transgenic mice. Brain Res. 666: 151–167
  13. Rall GF, Mucke L, Nerenberg M, and Oldstone MBA (1994) A transgenic mouse model to assess the interaction of cytotoxic T lymphocytes with virally infected, class I MHC-expressing astrocytes. J. Neuroimmunol. 52: 61–68
  14. Toggas SM, Masliah E, Rockenstein EM, Rall GF, Abraham CR, and Mucke L (1994) Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice. Nature 367: 188–193
  15. Borrow P, Cornell JL, Ruppe MD, and Mucke L (1995) Immunization-induced inflammatory infiltration of the CNS in transgenic mice expressing a foreign antigen in astrocytes. J. Neuroimmunol. 61: 133–149
  16. Games D, Adams D, Alessandrini R, Barbour R, Berthelette P, Blackwell C, Carr T, Clemens J, Donaldson T, Gillespie F, Guido T, Hagopian S, Johnson-Wood K, Khan K, Lee M, Leibowitz P, Lieberburg I, Little S, Masliah E, McConlogue L, Montoya-Zavala M, Mucke L, Paganini L, and Penniman L (1995) Alzheimer-type neuropathology in transgenic mice overexpressing V717F b-amyloid precursor protein. Nature 373: 523–527
  17. Johnson WB, Ruppe MD, Rockenstein EM, Price J, Sarthy VP, Verderber LC, and Mucke L (1995) Indicator expression directed by regulatory sequences of the glial fibrillary acidic protein (GFAP) gene: In vivo comparison of distinct GFAP-lacZ transgenes. Glia 13: 174–184
  18. Mucke L, Abraham CR, Ruppe MD, Rockenstein EM, Toggas SM, Alford M, and Masliah E (1995) Protection against HIV-1 gp120-induced brain damage by neuronal expression of amyloid precursor protein. J. Exp. Med. 181: 1551–1556
  19. Race RE, Priola SA, Bessen RA, Ernst D, Dockter J, Rall GF, Mucke L, Chesebro B, and Oldstone MBA (1995) Neuron-specific expression of a hamster prion protein minigene in transgenic mice induces susceptibility to hamster scrapie agent. Neuron 15: 1183–1191
  20. Rall GF, Mucke L, and Oldstone MBA (1995) Consequences of cytotoxic T lymphocyte interaction with MHC class I-expressing neurons in vivo. J. Exp. Med. 182: 1201–1212
  21. Rockenstein E, McConlogue L, Tan H, Gordon M, Power M, Masliah E, and Mucke L (1995) Levels and alternative splicing of amyloid b protein precursor (APP) transcripts in brains of transgenic mice and humans with Alzheimer’s disease. J. Biol. Chem. 270: 28257–28267
  22. Verderber L, Johnson W, Mucke L, and Sarthy V (1995) Differential regulation of a GFAP-lacZ transgene in retinal astrocytes and Müller cells. Invest. Ophthalmol. Vis. Sci. 36: 1137–1143
  23. Wyss-Coray T, Feng L, Masliah E, Ruppe MD, Lee HS, Toggas SM, Rockenstein EM, and Mucke L (1995) Increased central nervous system production of extracellular matrix components and development of hydrocephalus in transgenic mice overexpressing transforming growth factor-b1. Am. J. Pathol. 147: 53–67
  24. D’Hooge R, Nagels G, Westland CE, Mucke L, and De Deyn PP (1996) Spatial learning deficit in mice expressing human 751-amino acid b-amyloid precursor protein. Neuroreport 7: 2807–2811
  25. Masliah E, Sisk A, Mallory M, Mucke L, Schenk D, and Games D (1996) Comparison of the neurodegenerative pathology in transgenic mice overexpressing V717F b-amyloid precursor protein and Alzheimer’s disease. J. Neurosci. 16: 5795–5811
  26. Mohajeri MH, Bartsch U, van der Putten H, Sansig G, Mucke L, and Schachner M (1996) Neurite outgrowth on non-permissive substrates in vitro is enhanced by ectopic expression of the neural adhesion molecule L1 by mouse astrocytes. Eur. J. Neurosci. 8: 1085–1097
  27. Raber J, Toggas SM, Lee S, Bloom FE, Epstein CJ, and Mucke L (1996) Central nervous system expression of HIV-1 gp120 activates the hypothalamic-pituitary-adrenal axis: Evidence for an involvement of NMDA receptors and nitric oxide synthase. Virology 226: 362–373
  28. Toggas SM, Masliah E, and Mucke L (1996) Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist memantine. Brain Res. 706: 303–307
  29. Wyss-Coray T, Masliah E, Toggas SM, Rockenstein EM, Brooker MJ, Lee HS, and Mucke L (1996) Dysregulation of signal transduction pathways as a potential mechanism of nervous system alterations in HIV-1 gp120 transgenic mice and humans with HIV-1 encephalitis. J. Clin. Invest. 97: 789–798
  30. Zhao J, Paganini L, Mucke L, Gordon M, Refolo L, Carman M, Sinha S, Oltersdorf T, Lieberburg I, and McConlogue L (1996) b-secretase processing of the b-amyloid precursor protein in transgenic mice is efficient in neurons but inefficient in astrocytes. J. Biol. Chem. 271: 31407–31411
  31. Masliah E, Westland CE, Rockenstein EM, Abraham CR, Mallory M, Veinberg I, Sheldon E, and Mucke L (1997) Amyloid precursor proteins protect neurons of transgenic mice against acute and chronic excitotoxic injuries in vivo. Neuroscience 78: 135–146
  32. Raber J, Chen S, Mucke L, and Feng L (1997) Corticotropin-releasing factor and adrenocorticotrophic hormone as potential central mediators of OB effects. J. Biol. Chem. 272: 15057–15060
  33. Raeber AJ, Race RE, Brandner S, Priola SA, Sailer A, Bessen RA, Mucke L, Manson J, Aguzzi A, Oldstone MBA, Weissmann C, and Chesebro B (1997) Astrocyte-specific expression of hamster prion protein (PrP) renders PrP knockout mice susceptible to hamster scrapie. EMBO J. 16: 6057–6065
  34. Wyss-Coray T, Borrow P, Brooker MJ, and Mucke L (1997) Astroglial overproduction of TGF-b1 enhances inflammatory central nervous system disease in transgenic mice. J. Neuroimmunol. 77: 45–50
  35. Wyss-Coray T, Masliah E, Mallory M, McConlogue L, Johnson-Wood K, Lin C, and Mucke L (1997) Amyloidogenic role of cytokine TGF-b1 in transgenic mice and in Alzheimer’s disease. Nature 389: 603–606
  36. Xu X, Raber J, Yang D, Su B, and Mucke L (1997) Dynamic regulation of c-jun N-terminal kinase activity in mouse brain by environmental stimuli. Proc. Natl. Acad. Sci. USA 94: 12655–12660
  37. Bush TG, Savidge TC, Freeman TC, Cox HJ, Campbell EA, Mucke L, Johnson MH, and Sofroniew MV (1998) Fulminant jejuno-ileitis following ablation of enteric glia in adult transgenic mice. Cell 93: 189–201
  38. Buttini M, Westland CE, Masliah E, Yafeh AM, Wyss-Coray T, and Mucke L (1998) Novel role of human CD4 molecule identified in neurodegeneration. Nat. Med. 4: 441–446
  39. Krucker T, Toggas SM, Mucke L, and Siggins GR (1998) Transgenic mice with cerebral expression of human immunodeficiency virus type-1 coat protein gp120 show divergent changes in short- and long-term potentiation in CA1 hippocampus. Neuroscience 83: 691–700
  40. Masliah E, Raber J, Alford M, Mallory M, Mattson MP, Yang D, Wong D, and Mucke L (1998) Amyloid protein precursor stimulates excitatory amino acid transport: Implications for roles in neuroprotection and pathogenesis. J. Biol. Chem. 273: 12548–12554
  41. Raber J, Wong D, Buttini M, Orth M, Bellosta S, Pitas RE, Mahley RW, and Mucke L (1998) Isoform-specific effects of human apolipoprotein E on brain function revealed in Apoe knockout mice–Increased susceptibility of females. Proc. Natl. Acad. Sci. USA 95: 10914–10919
  42. Hsia A, Masliah E, McConlogue L, Yu G, Tatsuno G, Hu K, Kholodenko D, Malenka R, Nicoll R, and Mucke L (1999) Plaque-independent disruption of neural circuits in Alzheimer’s disease mouse models. Proc. Natl. Acad. Sci. USA 96: 3228–3233
  43. Buttini M, Orth M, Bellosta S, Akeefe H, Pitas RE, Wyss-Coray T, Mucke L, and Mahley RW (1999) Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: Isoform-specific effects on neurodegeneration. J. Neurosci. 19: 4867–4880
  44. Xu X, Yang D, Wyss-Coray T, Yan J, Gan L, Sun Y,and Mucke L (1999) Wild-type but not Alzheimer-mutant amyloid precursor protein confers resistance against p53-mediated apoptosis. Proc. Natl. Acad. Sci. USA 96: 7547–7552
  45. Bush TG, Puvanachandra N, Horner CH, Polito A, Ostenfeld T, Svendsen CN, Mucke L, Johnson MH, and Sofroniew MV (1999) Leukocyte infiltration, neuronal degeneration, and neurite outgrowth after ablation of scar-forming, reactive astrocytes in adult transgenic mice. Neuron 23: 1–20
  46. Sofroniew MV, Bush TG, Blumauer N, Kruger L, Mucke L and Johnson MH (1999) Genetically-targeted and conditionally-regulated ablation of astroglial cells in the central, enteric and peripheral nervous systems in adult transgenic mice. Brain Res. 835: 91–95
  47. Huang F, Buttini M, Wyss-Coray T, McConlogue L, Kodama T, Pitas RE, and Mucke L (1999) Elimination of the class A scavenger receptor does not affect amyloid plaque formation or neurodegeneration in transgenic mice expressing human amyloid protein precursors. Am. J. Pathol. 155: 1741–1747
  48. D’Hooge R, Franck F, Mucke L, and De Deyn PP (1999) Age-related behavioural deficits in transgenic mice expressing the HIV-1 coat protein gp120. Eur. J. Neurosci. 11: 1–5
  49. Wyss-Coray T, Lin C, Sanan DA, Mucke L, and Masliah E (2000) Chronic overproduction of transforming growth factor-b1 in astrocytes promotes Alzheimer’s disease-like microvascular degeneration in transgenic mice. Am. J. Pathol. 156: 139–150
  50. Raber J, Wong D, Yu G-Q, Buttini M, Mahley RW, Pitas RE, and Mucke L (2000) Alzheimer’s disease: Apolipoprotein E and cognitive performance. Nature 404: 352–354
  51. Masliah E, Rockenstein E, Veinbergs I, Mallory M, Hashimoto M, Takeda A, Sagara Y, Sisk A, and Mucke L (2000) Dopaminergic loss and inclusion body formation in a-synuclein mice: Implications for neurodegenerative disorders. Science 287: 1265–1269
  52. Raber J, Akana SF, Bhatnagar S, Dallman MF, Wong D, and Mucke L (2000) Hypothalamic-pituitary-adrenal dysfunction in Apoe -/- mice: Possible role in behavioral and metabolic alterations. J. Neurosci. 20: 2064–2071
  53. Buttini M, Akeefe H, Lin C, Mahley RW, Pitas RE, Wyss-Coray T, and Mucke L (2000) Dominant negative effects of apolipoprotein E4 revealed in transgenic models of neurodegenerative disease. Neuroscience 97: 207–210
  54. Mucke L, Masliah E, Yu G-Q, Mallory M, Rockenstein EM, Tatsuno G, Hu K, Kholodenko D, Johnson-Wood K, and McConlogue L (2000) High-level neuronal expression of Ab1-42 in wild-type human amyloid protein precursor transgenic mice: Synaptotoxicity without plaque formation. J. Neurosci. 20: 4050–4058
  55. Mucke L, Yu G-Q, McConlogue L, Rockenstein EM, Abraham CR, and Masliah E (2000) Astroglial expression of human a1-antichymotrypsin enhances Alzheimer-like pathology in amyloid protein precursor transgenic mice. Am. J. Pathol. 157: 2003–2010
  56. Wyss-Coray T, Lin C, Yan F, Yu G-Q, Rohde M, McConlogue L, Masliah E, and Mucke L (2001) TGF-b1 promotes microglial amyloid-b clearance and reduces plaque burden in transgenic mice. Nat. Med. 7: 612–618
  57. Masliah E, Rockenstein E, Veinbergs I, Sagara Y, Mallory M, Hashimoto M, and Mucke L (2001) b-Amyloid peptides enhance a-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer’s disease and Parkinson’s disease. Proc. Natl. Acad. Sci. USA 98: 12245–12250
  58. Raber J, LeFevour A, Buttini M, and Mucke L (2002) Androgens protect against apoE4-induced cognitive deficits. J. Neurosci. 22: 5204–5209
  59. Buttini M, Shockley K, Yu G-Q, Masliah E, Mallory M, Yeo T, Longo FM, and Mucke L (2002) Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging and overexpression of Ab but not on plaque formation. J. Neurosci. 22: 10539–10548
  60. Palop J, Jones B, Kekonius L, Chin J, Yu G-Q, Raber J, Masliah E, and Mucke L (2003) Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer’s disease-related cognitive deficits. Proc. Natl. Acad. Sci. USA 100: 9572–9577
  61. Harris FM, Brecht WJ, Xu Q, Tesseur I, Kekonius L, Wyss-Coray T, Fish JD, Masliah E, Hopkins PC, Scearce-Levie K, Weisgraber KH, Mucke L, Mahley RW, and Huang Y (2003) Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer’s disease-like neurodegeneration and behavioral deficits in transgenic mice. Proc. Natl. Acad. Sci. USA 100: 10966–10971
  62. Chin J, Palop JJ, Yu G-Q, Kojima N, Masliah E, and Mucke L (2004) Fyn kinase modulates synaptotoxicity, but not aberrant sprouting, in human amyloid precursor protein transgenic mice. J. Neurosci. 24: 4692–4697
  63. Brecht WJ, Harris FM, Chang S, Tesseur I, Yu G-Q, Xu Q, Wyss-Coray T, Buttini M, Mucke L, Mahley RW, and Huang Y (2004) Neuron-specific apolipoprotein E4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice. J. Neurosci. 24: 2527–2534
  64. Cheng IH, Palop JJ, Esposito LA, Bien-ly N, Yan F, Mucke L. (2004) Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation. Nat. Med. 11: 1190–1192
  65. Esposito L, Gan L, Yu G-Q, Essrich C, and Mucke L (2004) Intracellularly generated amyloid-b peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells. J. Neurochem. 91: 1260–1274
  66. Rockenstein E, Mante M, Alford M, Adame A, Crews L, Hashimoto M, Esposito L, Mucke L, and Masliah E (2005) High b-secretase activity elicits neurodegeneration in transgenic mice despite reductions in amyloid-b levels: Implications for the treatment of Alzheimer’s disease. J. Biol. Chem. 280: 32957–32967
  67. Palop JJ, Chin J, Bien-Ly N, Massaro C, Yeung BZ, Yu G-Q, and Mucke L (2005) Vulnerability of dentate granule cells to disruption of Arc expression in human amyloid precursor protein transgenic mice. J. Neurosci. 25: 9686–9693
  68. Chin J, Palop JJ, Puoliväli J, Massaro C, Bien-Ly N, Gerstein H, Scearce-Levie K, Masliah E, and Mucke L (2005) Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer’s disease. J. Neurosci. 25: 9694–9703
  69. Chen J, Zhou Y, Chen L.-F, Mueller-Steiner S, Chen L-F, Kwon H, Yi S, Mucke L, and Gan L (2005) SIRT1 protects against microglia-dependent beta amyloid toxicity through inhibiting NF-kB signaling. J. Biol. Chem. 280: 40364–40374
  70. Choi D.-S, Wang D, Yu G.-Q, Zhu G, Kharazia VN, Paredes JP, Chang WS, Deitchman JK Mucke L, and Messing RO (2006) PKC epsilon increases endothelin converting enzyme activity and reduces amyloid plaque pathology in transgenic mice. Proc. Natl. Acad. Sci. USA 103: 8215–8220
  71. Esposito L, Raber J, Kekonius L, Yan F, Yu GQ, Bien-Ly N, Puoliväli J, Scearce-Levie K, Masliah E, and Mucke L (2006) Reduction of mitochondrial superoxide dismutase modulates Alzheimer’s disease-like pathology and accelerates the onset of behavioral changes in human amyloid precursor protein transgenic mice. J. Neurosci. 26: 5167–5179
  72. Mueller-Steiner S, Zhou Y, Arai H, Roberson ED, Chen J, Wang X, Yu G.-Q, Esposito L, Mucke L, and Gan L (2006) Anti-amyloidogenic and neuroprotective functions of cathepsin B: Implications for Alzheimer’s disease. Neuron 51: 703–714
  73. Tesseur I, Zou K, Esposito L, Bard F, Berber E, Van Can J, Lin AH, Crews L, Tremblay P, Matthews P, Mucke L, Masliah E, and Wyss-Coray T (2006) Deficiency in neuronal TGF-b signaling promotes neurodegeneration and Alzheimer’s pathology. J. Clin. Invest. 116: 3060–3069
  74. Cheng IH, Scearce-Levie K, Legleiter J, Palop JJ, Gerstein H, Bien-Ly N, Puoliväli J, Lesné S, Ashe KH, Muchowski PJ, and Mucke L (2007) Accelerating Aβ fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models. J. Biol. Chem. 282: 23818–23828
  75. Chin J, Massaro CM, Palop JJ, Thwin MT, Yu G.-Q, Bien-Ly N, Bender A, and Mucke L (2007) Reelin depletion in the entorhinal cortex of human amyloid precursor protein transgenic mice and humans with Alzheimer’s disease. J. Neurosci. 27: 2727–2733
  76. deIpolyi AR, Rankin K, Mucke L, Miller B, and Gorno-Tempini ML (2007) Spatial cognition and the human navigation network in AD and MCI. Neurology 69: 986–997
  77. Palop JJ, Chin J, Roberson ED, Wang J, Thwin MT, Bien-Ly N, Yoo J, Ho KO, Yu G-Q,   Kreitzer A, Finkbeiner S, Noebels JL, and Mucke L (2007) Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of       Alzheimer’s disease. Neuron 55: 697–711
  78. Roberson ED, Scearce-Levie K, Palop JJ, Yan F, Cheng, IH, Wu T, Gerstein H, Yu G.-Q, and Mucke L (2007). Reducing endogenous tau ameliorates amyloid β-induced deficits in an Alzheimer’s disease mouse model. Science 316: 750–754
  79. deIpolyi AR, Fang S, Palop JJ, Yu G.-Q Wang X, and Mucke L (2008). Altered navigational strategy use and visuospatial deficits in hAPP transgenic mice. Neurobiol. Aging 29: 253–266
  80. Scearce-Levie K, Roberson ED, Gerstein H, Cholfin J, Mandiyan VS, Shah NM, Rubenstein JLR, and Mucke L (2008) Abnormal social behaviors in mice lacking Fgf17. Genes Brain Behav. 7: 344–354
  81. Meilandt WJ, Yu G.-Q, Chin J, Roberson ED, Palop JJ, Wu T, Scearce-Levie K, and Mucke L (2008) Enkephalin elevations contribute to neuronal and behavioral impairments in a transgenic mouse model of Alzheimer’s disease. J. Neurosci. 28: 5007–5017
  82. Sanchez-Mejia RO, Newman JW, Toh S, Yu G.-Q, Zhou Y, Halabisky B, Cisse M, Scearce-Levie K, Cheng IH, Gan L, Palop JJ, Bonventre JV, and Mucke L (2008) Phospholipase A2 reduction ameliorates cognitive deficits in mouse model of Alzheimer’s disease. Nat. Neurosci. 11: 1311–1318
  83. Tamgüney G, Giles K, Glidden DV, Lessard P, Wille H, Tremblay P, Groth DF, Yehiely F, Korth C, Moore RC, Tatzelt J, Rubinstein E, Boucheix C, Yang X, Stanley P, Lisanti MP, Dwek RA, Rudd PM, Moskovitz J, Epstein CJ, Cruz TD, Kuziel WA, Maeda N, Sap J, Ashe KH, Carlson GA, Tesseur I, Wyss-Coray T, Mucke L, Weisgraber KH, Mahley RW, Cohen FE, and Prusiner SB (2008) Genes contributing to prion pathogenesis. J. Gen. Virol. 89: 1777–1788
  84. Cheng JS, Dubal DB, Kim DH, Legleiter J, Cheng IH, Yu G-Q, Tesseur I, Wyss-Coray T, Bonaldo P, and Mucke L (2009) Collagen VI protects neurons against Ab toxicity. Nat. Neurosci. 12: 119–121
  85. Meilandt WJ, Cisse M, Ho K, Wu T, Esposito LA, Scearce-Levie K, Cheng IH, Yu GQ, and Mucke L (2009) Neprilysin overexpression inhibits plaque formation but fails to reduce pathogenic Ab oligomers and associated cognitive deficits in human amyloid precursor protein transgenic mice. J. Neurosci. 29: 1977–1986          
  86. Sun B, Halabisky B, Zhou Y, Yu G, Mucke L, and Gan L (2009) Imbalance between GABAergic and glutamatergic transmission impairs adult neurogenesis in an animal model of Alzheimer's disease. Cell Stem Cell 5: 624–633
  87. Harris HA, Devidze N, Halabisky B, Lo I, Thwin MT, Yu GQ, Bredesen DE, Masliah E, and Mucke L (2010) Many neuronal and behavioral impairments in transgenic mouse models of   Alzheimer’s disease are independent of caspase cleavage of the amyloid precursor protein. J. Neurosci. 30: 372–381
  88. Buttini M, Masliah E, Yu GQ, Palop JJ, Chang S, Bernardo A, Lin C, Wyss-Coray T, Huang Y,     and Mucke L (2010) Cellular source of apolipoprotein E4 determines neuronal susceptibility to      excitotoxic injury in transgenic mice. Am. J. Pathol. 177: 563–569
  89. Vossel K, Zhang K, Brodbeck J, Daub AC, Sharma P, Finkbeiner S, Cui B, and Mucke L (2010) Tau reduction prevents Aβ-induced defects in axonal transport. Science 330: 198
  90. Harris JA, Devidze N, Verret L, Ho K, Halabisky B, Thwin, MT, Kim D, Hamto T, Lo I, Yu G-Q, Palop JJ, Masliah E, and Mucke L (2010) Transsynaptic progression of amyloid-b-induced neuronal      dysfunction within the entorhinal-hippocampal network. Neuron 68: 428–441
  91. Cissé M, Halabisky B, Harris J, Devidze N, Dubal D, Sun B, Orr A, Lotz G, Kim DH, Hamto T, Ho K, Yu G-Q, and Mucke L (2011) Reversing EphB2 receptor depletion rescues cognitive functions in Alzheimer model. Nature 469: 47–52
  92. Roberson ED, Halabisky B, Yoo J, Yao J, Chin J, Yan F, Wu T, Hamto T, Devidze N, Yu G-Q, Palop JJ, Noebels JL, and Mucke L (2011) Amyloid-b/Fyn–induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer’s disease. J. Neurosci. 31: 700–711
  93. Cissé M, Sanchez PE, Kim DH, Ho, K, Yu G-Q, and Mucke L (2011) Ablation of cellular prion protein does not ameliorate abnormal neural network activity or cognitive dysfunction in the J20 line of human amyloid precursor protein transgenic mice. J. Neurosci. 31: 10427–10431
  94. Morris M, Koyama A, Masliah E, and Mucke L (2011) Tau reduction does not prevent motor deficits in two mouse models of Parkinson’s disease. PLoS One 6(12): e29257
  95. Minami SS, Sun B, Popat K, Kauppinen T, Pleiss M, Zhou Y, Ward ME, Floreancig P, Mucke L, Desai T, and Gan L (2012) Selective targeting of microglia by quantum dots. J. Neuroinflammation 9: 22
  96. Verret L, Mann EO, Hang GB, Barth AMI, Cobos I, Ho K, Devidze N, Masliah E, Kreitzer AC, Mody I, Mucke L, and Palop JJ (2012) Inhibitory interneuron deficit links altered network   activity and cognitive dysfunction in Alzheimer model. Cell 149: 1-14
  97. Sanchez PE, Zhu L, Verret L, Vossel KA, Orr, AG, Cirrito JR, Devidze N, Ho K, Yu G-Q, Palop JJ, and Mucke L (2012) Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer’s disease model. Proc. Natl. Acad. Sci. USA 109: E2895-E2903
  98. Harris JA, Koyama A, Maeda S, Ho K, Devidze N, Dubal DB, Yu G-Q, Masliah E, and Mucke L (2012) Human P301L-mutant tau expression in mouse entorhinal-hippocampal network causes tau aggregation and presynaptic pathology but no cognitive deficits. PLoS One 7(9): e45881
  99. Morris M, Hamto P, Adame A, Devidze N, Masliah E, and Mucke L (2013) Age-appropriate cognition and subtle dopamine-independent motor deficits in aged Tau knockout mice. Neurobiol. Aging 34: 1523–1529
  100. Suberbielle E, Sanchez PE, Kravitz AV, Wang X, Ho K, Eilertson K, Devidze N, Kreitzer AC, and Mucke L (2013) Physiological increases in brain activity cause DNA double strand breaks in neurons, with exacerbation by amyloid-b. Nat. Neurosci. 16: 616–621
  101. Vossel KA, Beagle AJ, Rabinovici GD, Shu H, Lee SE, Naasan G, Hegde M, Cornes SB, Henry ML, Nelson AB, Seeley WW, Geschwind MD, Gorno-Tempini ML, Shih T, Kirsch HE, Garcia PA; Miller BL, and Mucke L ­­(2013) Seizures and epileptiform activity in the early stages of Alzheimer’s disease. JAMA Neurology 70: 1158–1166