Selected Publications

Martinez-Losa, M., Tracy, T.E., Ma, K., Verret, L., Clemente-Perez, A., Khan, A.S., Cobos, I., Ho, K., Gan, L., Mucke, L., Alvarez-Dolado, M. & Palop, J.J. (2018) Nav1.1–overexpressing interneuron transplants restore brain rhythms and cognition in Alzheimer model. Neuron, 98, 1–15

Palop, J.J. & Mucke, L. (2016) Network abnormalities and interneuron dysfunction in Alzheimer disease. Nat. Rev. Neurosci., 17, 777–792.

Schachtrup, C., Ryu, J.K., Mammadzada, K., Khan, A.S., Carlton, P.M., Perez, A., Christian, F., Le Moan, N., Vagena, E., Baeza-Raja, B., Rafalski, V., Chan, J.P., Nitschke, R., Houslay, M.D., Ellisman, M.H., Wyss-Coray, T., Palop, J.J. & Akassoglou, K. (2015) Nuclear pore complex remodeling by p75(NTR) cleavage controls TGF-beta signaling and astrocyte functions. Nat. Neurosci., 18, 1077–1080.
 
Verret, L., Mann, E.O., Hang, G.B., Barth, A.M., Cobos, I., Ho, K., Devidze, N., Masliah, E., Kreitzer, A.C., Mody, I., Mucke, L. & Palop, J.J. (2012) Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model. Cell, 149, 708–721.
 
Sanchez, P.E., Zhu, L., Verret, L., Vossel, K.A., Orr, A.G., Cirrito, J.R., Devidze, N., Ho, K., Yu, G.-Q., Palop, J.J. & Mucke, L. (2012) Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer’s disease model. Proc. Natl. Acad. Sci. USA, 109, E2895–E2903.
 
Palop, J.J. & Mucke, L. (2010) Amyloid-β-induced neuronal dysfunction in Alzheimer’s disease: From synapses toward neural networks. Nat. Neurosci., 13, 812–818.
 
Harris, J.A., Devidze, N., Verret, L., Ho, K., Hamto, T., Lo, I., Yu, G.-Q., Palop, J.J., Masliah, E. & Mucke, L. (2010) Transsynaptic progression of amyloid-β-induced neuronal dysfunction within the entorhinal-hippocampal network. Neuron, 68, 428–441.
 
Palop, J.J. & Mucke, L. (2009) Epilepsy and cognitive impairments in Alzheimer disease. Arch. Neurol., 66, 435–440.
 
Palop, J.J., Chin, J., Roberson, E.D., Wang, J., Thwin, M.T., Bien-Ly, N., Yoo, J., Ho, K.O., Yu, G.-Q., Kreitzer, A., Finkbeiner, S., Noebels, J.L. & Mucke, L. (2007) Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer’s disease. Neuron, 55, 697–711.
 
Sanchez-Mejia, R.O., Newman, J.W., Toh, S., Yu, G.-Q., Zhou, Y., Halabisky, B., Cisse, M., Scearce-Levie, K., Cheng, I.H., Gan, L., Palop, J.J., Bonventre, J.V. & Mucke, L. (2008) Phospholipase A2 reduction ameliorates cognitve deficits in mouse model of Alzheimer’s disease. Nat. Neurosci., 11, 1311–1318.
 
Roberson, E.D., Scearce-Levie, K., Palop, J.J., Yan, F., Cheng, I.H., Wu, T., Gerstein, H., Yu, G.-Q. & Mucke, L. (2007) Reducing endogenous tau ameliorates amyloid β-induced deficits in an Alzheimer’s disease mouse model. Science, 316, 750–754.
 
Palop, J.J., Chin, J. & Mucke, L. (2006) A network dysfunction perspective on neurodegenerative diseases. Nature, 443, 768–773.
 
Palop, J.J., Chin, J., Bien-Ly, N., Massaro, C., Yeung, B.Z., Yu, G.-Q. & Mucke, L. (2005) Vulnerability of dentate granule cells to disruption of Arc expression in human amyloid precursor protein transgenic mice. J. Neurosci., 25, 9686–9693.
 
Cheng, I., Palop, J., Esposito, L., Bien-Ly, N., Yan, F. & Mucke, L. (2004) Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation. Nat. Med., 10, 1190–1192.
 
Palop, J.J., Jones, B., Kekonius, L., Chin, J., Yu, G.Q., Raber, J., Masliah, E. & Mucke, L. (2003) Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer’s disease-related cognitive deficits. Proc. Natl. Acad. Sci. USA, 100, 9572–9577.