Publications

SELECTED PEER-REVIEWED PUBLICATIONS
  1. Clemente Perez A, Ritter Makinson S, Higashikubo B, Brovarney S, Cho FS, Urry A, Holden SH, Wimer M, Dávid C, Fenno LE, Acsády L, Deisseroth K, Paz JT (2017) Distinct thalamic reticular cell types differentially modulate normal and pathological cortical rhythms. Cell Reports 19(10):2130–42.
  2. Sorokin JM, Davidson TJ, Frechette E, Abramian AM, Deisseroth K, Huguenard JR, Paz JT (2017) Bidirectional Control of Generalized Epilepsy Networks via Rapid Real-Time Switching of Firing Mode. Neuron 93:194-210.
  3. Lui H, Zhang J, Makinson SR, Cahill MK, Kelley KW, Huang HY, Shang Y, Oldham MC, Martens LH, Gao F, Coppola G, Sloan SA, Hsieh CL, Kim CC, Bigio EH, Weintraub S, Mesulam MM, Rademakers R, Mackenzie IR, Seeley WW, Karydas A, Miller BL, Borroni B, Ghidoni R, Farese RV Jr, Paz JT, Barres BA, Huang EJ (2016) Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation. Cell 165(4):921-35.
  4. Hiu T, Farzampour Z, Paz JT, Wang EHou Jen, Badgely C, Olson A, Micheva KD, Wang G, Lemmens R, Tran KV et al. (2016) Enhanced phasic GABA inhibition during the repair phase of stroke: a novel therapeutic target. Brain 139(Pt 2):468-80.
  5. Paz JT, Davidson T, Frechette E, Delord B, Parada I, Peng K, Deisseroth K, Huguenard JR (2013) Closed-loop optogenetic control of thalamus as a novel tool to interrupt seizures after cortical injury. Nature Neuroscience 16(1):64-70.
  6. Naudé J, Paz JT, Berry H, Delord B (2012) A Theory of Rate Coding control by intrinsic plasticity. PloS Computational Biology 8(1):e1002349.
  7. Yizhar O, Fenno LE, Prigge M, Schneider F, Davidson TJ, O'Shea DJ, Sohal VS, Goshen I, Finkelstein J, Paz JT, Stehfest K, Fudim R, Ramakrishnan C, Huguenard JR, Hegemann P, Deisseroth K (2011) Neocortical excitation/inhibition balance in information processing and social dysfunction. Nature 477:171-8.
  8. Paz JT, Bryant A, Fenno LE, Yizhar O, Peng K, Deisseroth K, Huguenard JR (2011) A new mode of corticothalamic transmission revealed in the Gria4-/- model of absence epilepsy. Nature Neuroscience 21:14:1167-73.
  9. Paz JT, Christian CA, Parada I, Prince DA, Huguenard JR (2010) Focal cortical infarcts alter intrinsic excitability and synaptic excitation in the reticular thalamic nucleus. Journal of Neuroscience 30:5465-79.
  10. Paz JT, Mahon S, Tiret P, Genet S, Delord B, Charpier S (2009) Multiple forms of activity-dependent intrinsic plasticity in layer V cortical neurones in vivo. Journal of Physiology 587:3189-205.
  11. Paz JT, Chavez M, Saillet S, Deniau J-M, Charpier S (2007) Activity of Ventral Medial Thalamic Neurons during Absence Seizures and Modulation of Cortical Paroxysms by the Nigrothalamic Pathway. Journal of Neuroscience 27:929-41
  12. Paz JT, Deniau JM, Charpier S (2005) Rhythmic bursting in the Cortico-Subthalamo-Pallidal pathway during spontaneous Genetically Determined Spike and Wave Discharges. Journal of Neuroscience 25(8):2092-101
  13. Slaght SJ, Paz T, Chavez M, Deniau JM, Mahon S, Charpier S (2004) On the activity of the corticostriatal networks during spike-and-wave discharges in a genetic model of absence epilepsy. Journal of Neuroscience 24:6816-25
SELECTED PEER-REVIEWED REVIEWS
  1. Paz JT, Huguenard JR (2015) Microcircuits and their interactions in epilepsy: is the focus out of focus? Nature Neuroscience 18(3):351-9.
  2. Paz JT, Huguenard JR (2015) Optogenetics and Epilepsy: past, present and future. Epilepsy Currents January/February, 15:34-38.
  3. Paz JT, Huguenard JR (2012) R U OK? The Novel Therapeutic Potential of R Channels in Epilepsy. Epilepsy Currents 12:75–76.
  4. Slaght SJ, Paz T, Mahon S, Maurice N, Charpier S, Deniau JM (2002) Functional organization of the circuits connecting the cerebral cortex and the basal ganglia: implications for the role of the basal ganglia in epilepsy. Epileptic Disorders 4 Suppl 3:S9-22.
COMMENTARIES
  1. Depaulis A, Blumenfeld H et al., (2017) eLetter and PubMed Commentary on Voluntary Control of Epileptiform Spike-Wave Discharges in Awake Rats. J Nsci 37(24):5861-5869.
  2. Amit I, Baker D, Barker R, Berger B, Bertozzi C, Bhatia S, Biffi A, Demichelis F, Doudna J, Dowdy SF et al.. 2016. Voices of biotech. Nature Biotechnol. 34(3):270-5.
BOOK CHAPTERS
  1. Cho F, Clemente A, Holden S, Paz JT (2017) Thalamic Models of Seizures In Vitro. In: Models of Seizures and Epilepsy, 2nd edition. Eds. Pitkänen A, Buckmaster P, Galanopoulou AS, Moshe SM. Chapter 19
  2. Charpier S, Beurrier C, Paz JT (2010) The subthalamic nucleus: from in vitro to in vivo mechanisms. In: Handbook of Basal Ganglia Structure and Function: A Decade of Progress. Eds. Steiner H and Tseng, KY. Elsevier. pp. 259-273
  3. Paz JT, Polack PO, Slaght SJ, Deniau JM, Chavez M, Mahon S, Charpier S (2009) Cortical initiation of absence seizures, propagation to basal ganglia and back to the cortex. Pan-Brain Abnormal Neural Networks in Epilepsy. Eds Feng Ru Tang. Research Signpost. Kerala. India. pp. 41-65
  4. Paz JT, Polack PO, Slaght SJ, Deniau JM, Mahon S, Charpier S (2006) Propagation and dynamic processing of cortical paroxysms in the basal ganglia networks during absence seizures. In: Progress in Epileptic Disorders series. Generalized seizures: from clinical phenomenology to underlying systems and networks. Eds. Hirsch E, Andermann F, Chauvel P, Engels J, Lopes da Silva F, Luders H. pp. 83-99
  5. Paz JT, Polack PO, Slaght SJ, Deniau JM, Charpier S (2005) Propagation of cortical paroxysms in basal ganglia circuits during absence seizures. In: The basal ganglia VIII. Eds. Bolam JP, Ingham CA, Magill PJ. New York: Springer. pp. 55–65
INVITED ORAL PRESENTATIONS
2018
  1. Weizmann Institute , Conference “Brain interfaces – bridging basic and translational neuroscience". Israel (Scheduled for January 2018)
  2. Gordon Research Conference 2018 – Thalamocortical Interactions. Lucca, Italy (Scheduled for February 2018)
  3. Grand Rounds CURE 2018 invited speaker – Calgary, Canada (Scheduled for 2018)

2017

  1. Society for Neuroscience, Minisymposium Short-circuiting neurodevelopmental disorders: novel insights and treatment strategies. Washington, DC, USA (Scheduled for November 2017)
  2. Grass Foundation, Marine Biological Laboratory, Seminar Series., Woods Hold, MA, USA
  3. University of Amsterdam, Seminar Series. Amsterdam, Netherlands.
  4. Institute of Brain and Spinal Cord, Seminar Series. Paris, France
  5. 2nd International Brain Stimulation Conference. Barcelona, Spain (March 2017)

2016

  1. International Society for Neurofeedback and Research, Keynote Speaker. Orlando, Florida
  2. ICM Epilepsy Retreat, Keynote Speaker. Sologne, France (Fall 2016).
  3. Gordon Research Conference, Mechanisms of Epilepsy and Neuronal Synchronization. Girona, Spain
  4. Cold Spring Harbor Asia Conference on Development, Function, and Disease of Neural Circuits. Suzhou, China
  5. Neuroethics Network meeting at ICM, June 29-July 1. Paris, France (declined for conflict with another event)
  6. Optogenetic Approaches for Pre-Clinical Studies at ICM. Paris, France
  7. Gordon Research Conference, Thalamocortical Interactions: Cell and Circuit Properties. Ventura, California
  8. GDR 2904 Multielectrode Systems for Neuroscience: 6th Annual Meeting. Autrans, France
  9. Erasmus MC, Rotterdam, The Netherlands

2015

  1. University of Bonn, Bonn, Germany
  2. The 31st International Epilepsy Congress - the Michael Prize Symposium. Istanbul, Turkey. (Invited talk to receive the Michael Prize 2015
  3. Janelia Conference on Thalamus and Corticothalamic Interactions. HHMI-Janelia Farm Research Campus, Virginia. 
  4. Cell Press LabLinks Symposium. San Francisco, California.  
  5. UCSF Annual Epilepsy Retreat. University of California, San Francisco, San Francisco, California.
  6. UCSF Neuroimmunology Seminar. University of California, San Francisco, San Francisco, California.

2014

  1. Rustavi 2 TV guest on morning news. Tbilisi, Georgia.
  2. The Saakashvili Presidential Library. Tbilisi, Georgia.
  3. Society for the Advancement of Brain Analysis (SABA) 13th Annual Conference. Avalon, California.
  4. Stanford University School of Medicine. Faculty recruitment job talk. 

2013

  1. Harvard Medical School, Boston. Faculty recruitment job talk. 
  2. American Epilepsy Society Annual Meeting, Translational Symposium, Washington DC. 
  3. UC Davis, Center for Neuroscience, Davis. Faculty recruitment job talk. 
  4. UCSF/Gladstone Institutes, San Francisco. Faculty recruitment job talk. 
  5. UC Davis, Neurology Grand Rounds, Davis. Faculty recruitment job talk.
  6. Computational and Systems Neuroscience (COSYNE) workshop, Snowbird, Utah. 

2012

  1. American Epilepsy Society Annual Meeting, Investigators Workshop, San Diego. 

2011

  1. Stanford Institute for Neuro-Innovation & Translational Neurosciences retreat, Pajaro Dunes, CA. 
  2. Bay Area Research Group in Epilepsy (BARGE) meeting, UCSF, San Francisco. 

2007

  1. International Basal Ganglia Society IX triennial meeting, Egmond aan Zee, Netherlands. Plenary session. 

2005

  1. Club EpilepsieS (French Epilepsy Club annual meetings), Paris, France. 

2004

  1. 2004 Basal Ganglia Club, Bordeaux, France. 
  2. 2004 Epilepsie/Recherche annual meetings, Venise, Italy. 

 

SELECTED ABSTRACTS
  1. Makinson SL, Clemente-Perez A, Higashikubo B, Delord B, Paz JT (2017) Deconstructing thalamic circuits to treat seizures in Dravet syndrome. Society for Neuroscience, Washington DC, USA
  2. Holden S, Paz JT (2017) Deconstruction of thalamic circuits in a mouse model of post- traumatic epilepsy. Society for Neuroscience, Washington DC, USA
  3. Clemente A, Makinson SL, Higashikubo B, Cho F, Urry A, Holden S, Wimer M, Fenno L, David C, Acsady L, Deisseroth K, Paz JT (2017) Distinct thalamic reticular cell types differentially modulate normal and pathological cortical rhythms. Society for Neuroscience, Washington DC, USA
  4. Pai LL, Vogt D, Clemente-Perez A, Wimer M, Mckinsey G, Hu JS, Sandberg M, Pla R, Goodrich LV, Paz JT, Rubenstein JL (2017) Mafb and c-Maf control the balanced neurogenesis of MGE-derived PV+ and SST+ GABAergic cortical interneurons. Society for Neuroscience, Washington DC, USA
  5. Cho F, Paz JT (2017) “Assessing the effect of astrogliosis on thalamic circuit excitability”. Young Generation Technical and Leadership Conference 2017 (YGTLC). Hosted by the Korean-American Scientist and Engineers Association, Korea
  6. Holden S, Paz JT (2016) “The Role of the thalamus in focal traumatic brain injury”. ARCS Symposium 2016, Menlo Park, CA, USA
  7. Holden S, Paz JT (2016) “Thalamic excitability after traumatic cortical injury”.GRC-Mechanisms of Epilepsy & Neuronal Synchronization conference, Girona, Spain
  8. Clemente A, Paz JT (2016)” Different subpopulations of interneurons in the nuclear reticular thalamus: anatomy and physiology” GRC-Mechanisms of Epilepsy & Neuronal Synchronization conference, Girona, Spain
  9. Cho F, Makinson S, Holden S, Tager D, Paz JT (2016) “Selective astrogliosis increases thalamic circuit excitability and oscillations” GRC-Mechanisms of Epilepsy & Neuronal Synchronization conference, Girona, Spain
  10. Makinson S, Clemente A, Bennet E, Paz JT (2016) “Optogenetic targeting of the thalamus for bidirectional control of seizures in Dravet syndrome” GRC-Mechanisms of Epilepsy & Neuronal Synchronization conference, Girona, Spain
  11. Saillet S, Gutierrez-Lerma A, Chou Z, Ma K, Paz JT, Palop J (2016) “Optogenetic modulation of interneuron-dependent oscillatory activity in mouse models of Alzheimer’s disease”. Society for Neuroscience Annual Meeting, San Diego, CA, USA
  12. Sorokin J, Huguenard JR, Paz JT (2016) “Real-Time control of generalized absence seizures” American Epilepsy Society” Seattle, WA, USA
  13. Makinson S, Clemente A, Bennett E, Yamakawa K, & Paz JT (2016) “Optogenetic Targeting of the Thalamus to Manipulate Seizure Expression in Dravet syndrome”. Gordon research conference on Thalamus. Ventura, CA, USA.
  14. Holden S, Paz JT (2016) “Thalamic function and traumatic cortical injury”. Gordon research conference on Thalamus. Ventura, CA, USA.
  15. Cho F, Makinson S, Holden S, Paz JT (2016) Assessing the effect of astrogliosis n thalamic circuit excitability”. Gordon research conference on Thalamus. Ventura, CA, USA.
  16. Clemente A, Paz JT (2016) “Different subpopulation of interneurons in the nuclear reticular thalamus”. Gordon research conference on Thalamus. Ventura, CA, USA.
  17. Huguenard JR, Sorokin J, Paz JT (2014) "Real-Time control of generalized absence seizures". American Epilepsy Society, Seattle, USA
  18. Paz JT, Sorokin J, Davidson TJ, Deisseroth K, Huguenard JR (2014) "Thalamic driving of cortical spindles and seizures with on demand loss of consciousness". Society for Neuroscience, Washington DC, USA
  19. Paz JT, Huguenard JR (2013) “Evidence of a functional feed-forward GABAergic inhibition between reticular thalamic neurons revealed by an optogenetic approach in the mouse”. Society for Neuroscience, San Diego, USA
  20. Huguenard JR, Davidson T, Frechette E, Deisseroth K, Paz JT (2012) “Selective optical inhibition of thalamocortical neurons as a novel tool to reliably drive thalamocortical oscillations and sleep-spindles”. Society for Neuroscience, New Orleans, USA
  21. Paz JT, Yizhar O, Fenno L, Deisseroth K, Huguenard JR (2012) “Dynamic interaction between cortical and thalamic inputs onto reticular thalamic neurons revealed by dual-wavelength optogenetics” Society for Neuroscience, New Orleans, USA
  22. Paz JT, Davidson T, Frechette E, Deisseroth K, Huguenard JR (2012) “Real-time control of post-stroke seizures”. Gordon Research Conference on Mechanisms of Epilepsy and Neuronal Synchronization, August 19-24, Waterville, USA
  23. Paz JT, Peng K, Parada I, Prince DA, Huguenard JR (2011) "Neocortical infarction results in epileptiform activity in thalamocortical neurons via a switch in HCN channel subunits". Society for Neuroscience, Washington DC, USA
  24. Fenno LE, Yizhar O, Prigge M, Paz JT, Ramkrishnan C, Huguenard JR, Hegemann P, Deisseroth K (2011) “Combinatorial optogenetics with integrated spectral and temporal control”. Society for Neuroscience, Washington DC, USA
  25. Paz JT, Bryant A, Fenno LE, Yizhar O, Peng K, Deisseroth K, Frankel WN, Huguenard JR (2011) “A new mechanism for absence seizure initiation revealed by optogenetics in the Gria4-/- knockout model of absence epilepsy“. “Coming together on Epilepsy Genetics” workshop. Bar Harbor, USA
  26. Delord B, Berry H, Paz JT, Naude J (2011) Modeling the Effects of intrinsic plasticity on rate coding. COSYNE, Computational and Systems Neuroscience conference. Salt Lake City, USA
  27. Paz JT, McDonald W, Prince DA, Huguenard JR (2010) Focal status epilepticus in the somatosensory cortex enhances intrinsic excitability and synaptic excitation in the reticular thalamic nucleus. Investigators Workshop, American Epilepsy Society, San Antonio, Texas, USA
  28. Paz JT, Prince DA, Huguenard JR (2010) Focal cortical infarcts increase intrinsic excitability and synaptic excitation of thalamocortical relay neurons. Gordon Research Conference on Mechanisms of Epilepsy and Neuronal Synchronization, Colby College, Waterville, USA
  29. Paz JT, Lacey CJ, Bryant A, Huguenard JR (2009) Altered intrathalamic GABAergic neurotransmission in the Glur4 knock-out mouse model of absence epilepsy. American Epilepsy Society, Boston, USA
  30. Paz JT, Prince DA, Huguenard JR (2008) Altered excitability of the thalamic reticular neurons following cortical thrombotic lesions. Society for Neuroscience, Washington DC, USA
  31. Paz JT, Deniau JM, Charpier S (2006) Presentation title: “Electrical activity of ventral medial thalamic neurons during spike-and-wave discharges and control of seizures by the nigro-thalamo-cortical pathway”. Society for Neuroscience, Atlanta, USA
  32. Paz JT, Mailly P, Deniau JM, Charpier S (2005) Electrophysiological activity in the corticosubthalamic pathway during spike-and-wave discharges in a genetic model of absence epilepsy. French Society for Neuroscience, Lille, France
  33. Paz JT, Mailly P, Deniau JM, and Charpier S (2004) Electrophysiological Activity of Subthalamic Neurons During Spike-and-Wave Discharges in a Genetic Model of Absence Epilepsy. International Basal Ganglia Society VIII triennial meeting, Crieff, Scotland