Areas of Investigation
Our group develops statistical and computational methods for the analysis of massive genomic datasets. We are interested in genome evolution, in particular identifying genome sequences that differ significantly between or within species and their relationship to biomedical traits of interest. Many of these sequences are non-coding, such as regulatory signals, structural sites, and RNA genes. One of our aims is to identify specific DNA alterations that are responsible for variation in gene expression. Current projects focus on two major areas: (1) fast evolving regions of the human genome and (2) adaptive evolution in microbial communities.
Our human research makes use of the increasing number of vertebrate whole genome sequences as well as human population genomic data.